BCL2 and cancer: ABT-737 binds to Bcl-xL, Bcl-2, and Bcl-w with high affinity (Ki≤1 nM), while it binds to Mcl-1 with Ki=1>μM.7 Therefore ABT-737 could induce apoptosis in several cancer cells, which highly expressed anti-apoptotic Bcl-2 family.