TACC3 and cancer: Recently, TACC3 has attracted increasing attention as a target for cancer therapy,21, 34, 35, 36, 37, 38, 39, 40, 41 and inhibitors of TACC3 have been reported to possess anti-tumor activity.42 As SNIPER(TACC3) exhibits selective toxicity to cancer cells aberrantly expressing large amount of the TACC3 protein as compared with normal cells, protein knockdown is a strategy for disrupting TACC3 function in cancer cells.