SNIPER(TACC3)s also decreased the cIAP1 level, although the effect was less than Me-BS, suggesting that the SNIPER(TACC3)s simultaneously induces auto-ubiquitylation and proteasomal degradation of cIAP1, as observed with other SNIPERs.22, 28 Similar results were obtained in human breast adenocarcinoma MCF7 or human osteosarcoma U2OS cells when the cells were treated with 30 μM of SNIPER(TACC3)s for 6 h (Figure 1c). This evidence concerns the gene BIRC2 and osteosarcoma.