Degradation of TACC3 seems to have an important role in the SNIPER(TACC3)-induced apoptosis, because downregulation of APC/CCDH1-components by siRNA abrogates the SNIPER(TACC3)-induced TACC3 degradation (Figure 3), and suppresses cell death (Supplementary Figure S6), though TACC3 depletion by siRNA is not enough to induce cell death in these cancer cells (Supplementary Figure S5),. The gene discussed is APC; the disease is cancer.