Cathepsins are lysosomal proteases required for autophagic degradation processes,51 and they are important for the death, proliferation, and invasion of human cancer cells.36 Cathepsins are overexpressed in many carcinomas and frequently associated with poor clinical prognoses.52, 53 We found that bortezomib decreased the activity of lysosomal degradation without inhibition of the fusion between autophagosome and lysosome. The gene discussed is CTSS; the disease is carcinoma.