SQSTM1 and neoplasm: Complete degradation results in heterogeneous contents and single membrane structures.20, 21, 22 P62/sequestosome 1 (p62/SQTM1) is a useful indicator to monitor autophagy, because it decreases when autophagy is completed.23 P62 accumulates in autophagic-defective tumor cells.19 In short, p62 degradation is autophagy-dependent.24, 25, 26