Rottlerin displayed antioxidant properties and inhibitory effect on NF-κB in breast and colon cancer cells.71 In fact, in these cells, expressions of PKCδ and TG2 led to activation of NF-κB,72, 73 whereas inhibition led to induction of autophagy death.74 Importantly, rottlerin is accepted widely as a PKCδ-selective inhibitor. Here, PRKCD is linked to colonic neoplasm.