PELP1 and lung cancer: Resveratrol was shown to bind to a novel estrogen receptor coactivator, PELP1, and induce its accumulation in autophagosomes.109 PELP1 was identified for the first time by a trafficking molecule, hepatocyte growth factor-regulated tyrosine kinase substrate, which binds to it.110 The role of hepatocyte growth factor-regulated tyrosine kinase substrate in facilitating the transport of cytoplasmic proteins to autophagosomes for their selective degradation was confirmed in another study involving resveratrol treatment of lung cancer cells.111