Resveratrol was shown to bind to a novel estrogen receptor coactivator, PELP1, and induce its accumulation in autophagosomes.109 PELP1 was identified for the first time by a trafficking molecule, hepatocyte growth factor-regulated tyrosine kinase substrate, which binds to it.110 The role of hepatocyte growth factor-regulated tyrosine kinase substrate in facilitating the transport of cytoplasmic proteins to autophagosomes for their selective degradation was confirmed in another study involving resveratrol treatment of lung cancer cells.111. The gene discussed is PELP1; the disease is lung carcinoma.