The first evidence of massive autophagy induction leading to death only in cells with PKCδ via induction of TG2 was reported in pancreatic cancer cells.12, 13 However, recent studies suggested that rottlerin can also induce apoptosis through PKCδ-independent mechanisms in fibrosarcoma cells.75 It was suggested that the early autophagy might serve as a survival mechanism against late apoptosis in this cancer type.76 Here, TGM2 is linked to fibrosarcoma.