Rottlerin inhibition of NF-κB was able to induce AMPK induction, which led to significantly reduced cellular ATP levels and induction of autophagy in cancer cells.78 AMPK can also activate the cyclin-dependent kinase inhibitor, p27, by a mechanism involving the SIRT1/FOXO pathway to induce autophagy.79 This evidence concerns the gene NFKB1 and cancer.