AKT1 and neoplasm: Various studies provided evidence that curcumin induced G2/M arrest and autophagy in malignant glioma cells through inhibition of the Akt/mTOR/p70S6K and activation of the ERK1/2 pathways, which implied that cell death via autophagy, might be pathway specific.62, 96, 97 In a xenograft glioma model, Aoki et al.96 observed that curcumin induced autophagy and inhibited tumor growth significantly.