Curcumin induced autophagy in mesothelioma cells as indicated by increased conversion of LC3-I to LC3-II and formation of autophagosomes, which were reduced by RNA silencing of Atg5.100 Mosieniak et al.101 showed that induction of cellular senescence was accompanied by autophagy in colon cancer cells with an increase in Beclin-1 and p62/SQSTM1 protein levels. The gene discussed is SQSTM1; the disease is mesothelioma.