Numerous reports link inflammation with tumorigenesis, angiogenesis and metastasis.10 Based on that, it could be speculated that, within the tumor microenvironment, TIS-T cell/macrophage interaction may certainly have important consequences for tumor progression since TIS-T cells promote the production of mediators such as TNF, IL-1β and IL-6. The gene discussed is TNF; the disease is neoplasm.