Fig. 10 A–D shows that exposure of cells to filipin III, 30 min prior to infection and during virus absorption, practically abolished the NF-κB-luc activation induced by gD−/− virions (Fig. 10 A), the degradation of endogenous IκB-α seen at 2 h after cell exposure to virus (Fig. 10 B), the Akt phosphorylation (Fig. 10 C), and IFN-β secretion at 48 h. The gene discussed is PAEP; the disease is infection.