HNF4A and colorectal carcinoma: (N-3) PUFA efficacy in ameliorating the course of CRC development has been ascribed to modulation of COX activity, disruption of cell surface lipid rafts, increased oxidative stress, and modulation of the activity of specific transcription factors (e.g. HNF-4α, PPARγ/RXR, SREBP1c) (reviewed in [10]).