Indeed, MEDICA analogs combine the two features of counteracting diabetes in animal models (e.g., Zucker, cp/cp, db/db, ob/ob) [16-19], while mimicking (n-3) PUFA in suppressing HNF-4α transcriptional activity [15, 20], and in activating AMPK [38]. This evidence concerns the gene HNF4A and diabetes mellitus.