In line with that, introducing the fat-1 gene into the obese diabetic context resulted in suppressing β-catenin/Tcf-responsive transcripts (e.g., axin-2, tcf-4 and c-myc) (Fig 4F), implying decrease in β-catenin/Tcf-induced CRC progression. This evidence concerns the gene FAT1 and colorectal carcinoma.