Some patterns of AS have been found to correlate with tumor aggressiveness in solid tumors [58] while in AML, the expression of certain isoforms, such as for WT1 itself, TP53 [60], HOXA9 [61], BAALC [62], VEGF [58], or BCL-X [63], have been found to exhibit distinct effects on disease outcome. This evidence concerns the gene WT1 and acute myeloid leukemia.