CXCL2 and infection: Although not affecting the fungal burden in the lung (Figure 1A), IL-37 administered 1 h before the infection at the dosage of 1000 and 100 ng/mouse (50 and 5 μg/kg, respectively) reduced BAL neutrophilia (Figure 1B), neutrophil influx in the lung (Figure 1C), lung damage (Figure 1C, insets) and lung expression of Mpo and CxCl2, an essential mediator of host defense against A. fumigatus in mice [24] and humans [25].