IL1R1 and aspergillosis: However, given that IL-1R1-deficient or caspase 1-deficient mice are resistant to lung inflammation during aspergillosis [20], [22] and that IL-1 signaling could drive the differentiation of antifungal inflammatory Th17 cells [20], [23], the proinflammatory properties of IL-1-induced inflammation in aspergillosis is potentially dangerous for the host.