HNRNPA1 and amyotrophic lateral sclerosis: Moreover, mutations in heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1; OMIM*164017) and A2/B1 (hnRNPA2B1; OMIM*600124) have been described in families with multisystem proteinopathy and ALS [11], TATA box-binding protein-associated factor 2N (TAF15; OMIM*601574) and Ewing sarcoma breakpoint region 1 (EWRS1; OMIM*133450) have been implicated both in ALS and frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTDL-U) [12]–[14].