DUSP2 and obesity due to melanocortin 4 receptor deficiency: Based on the key role of immune cells and inflammation in obesity-associated insulin resistance, the roles ascribed to certain DUSPs in the regulation of obesity and insulin resistance, high level DUSP2 expression in various activated immune cells, plus reduced inflammation in vitro and in vivo in DUSP2-deficient cells, we have examined the role of DUSP2 in the context of obesity-associated inflammation and insulin resistance.