[39], [40], [41] Moreover, in other retinal disease models, including acute inflammation and diabetes, excessive arginase 1 has been shown to dysregulate endothelial function through interfering with NOS function. [8], [42], [43] These differences suggest that differences in vascular maturity, target tissue and/or specific disease-associated triggers determine the arginase isoform involved in vascular injury. This evidence concerns the gene ARG1 and diabetes mellitus.