In a prospective study of children admitted with fever without a clear focus to St Lukes Medical Centre in Quezon City, Metro Manila, from January 1999 to December 2001, 71.4% had dengue (confirmed by IgM and/or RT-PCR) and 1/3 had DHF [47], [48]. The gene discussed is CD40LG; the disease is Dengue hemorrhagic fever.