To determine if the cytotoxic effects of this combination are limited to these three cell lines, two additional NSCLC cell lines, namely NCI-H2122 (EGFR wt, KRAS mutation, LKB1 inactivation) and NCI-H3122 (EGFR wt, EML4/ALK translocation), were taken for further investigation. The gene discussed is KRAS; the disease is non-small cell lung carcinoma.