(Fig. 5C-E) Moreover, a marker of angiogenesis (platelet/endothelial cell adhesion molecule 1, PECAM1) and a key component of this pathway (hypoxia inducible factor 1A, HIF1A) were both more obviously reduced in the tumor tissue from the high-dose AUY922 alone and low-dose AUY922/rapamycin treated mice compared with those from each treatment alone. Here, HIF1A is linked to neoplasm.