KIT and neoplasm: Immunohistochemical staining of tumor tissue sections from the GIST430 xenograft revealed that low-dose AUY922/rapamycin combo, as well as high-dose AUY922, induced more prominent tumor necrosis, as visualized by hematoxylin and eosin (H&E) staining, and achieved a more pronounced effect on KIT downregulation and MAP1LC3B accumulation than low-dose AUY922 or rapamycin alone in vivo.