In clinical practice, for patients with SLE and aPL positivity, a biopsy procedure is necessary to differentiate inflammatory damage from thrombotic damage, since the therapeutic approaches are quite different; moreover, renal damage due to APS on kidney histology seriously affects lupus nephritis outcome and long-term anticoagulant therapy has been recommended for such patients [27]. This evidence concerns the gene FASLG and systemic lupus erythematosus.