Indeed not only SLE patients could present aPL positivity associated with vascular involvement or obstetrical disease, but also APS patients could present some SLE features, such as autoimmune hemolytic anemia and mild reduction in complement, anti-nuclear antibodies (ANA); interestingly, these patients can be considered as APS patients who likely will evolve into SLE over time. This evidence concerns the gene FASLG and autoimmune polyendocrinopathy.