A large scale study of 83 radiation induced sarcomas and 192 sporadic sarcomas indicated that MYC amplification was a distinguishing characteristic in radiation induced angiosarcomas, undifferentiated pleomorphic sarcomas, and leiomyosarcomas; however, the authors present significant evidence to suggest that angiosarcomas were unique amongst other sarcomas in that MYC amplifications were particularly frequent and at high levels in angiosarcomas, while other radiation induced sarcomas displayed low level MYC amplifications [60]. The gene discussed is MYC; the disease is undifferentiated pleomorphic sarcoma.