Arthritis, fever, serositis, Raynaud's syndrome, lung disease, neuropsychiatric symptoms, positive antinuclear antibody tests, positive rheumatoid factor, positive anti-Ro/Sjögren's syndrome (SS) A, and positive anti-La/SSB are more common in patients with elderly-onset lupus. The gene discussed is SSB; the disease is systemic lupus erythematosus.