Review of the literature revealed a few reported cases of pediatric and adult patients with SIgMID and celiac disease [3, 7, 10–12] while all reported cases were without unusual risk of infection and in all patients IgM levels returned to normal levels following a gluten-free diet [3, 10, 12] Therefore, our case is the first report of symptomatic secondary SIgMID associated with celiac disease. This evidence concerns the gene CD40LG and celiac disease.