Organ-specific variations, differences between microvessels and large vessels, and different effects on the vessel-surrounding microenvironment by various parenchymal disorders may also explain why endothelial biomarker levels in acute liver GVHD (normal VCAM-1) differ from other liver diseases, for example, cirrhosis with increased hepatic vein pressure gradients showing increased systemic VCAM-1 levels [45]. Here, VCAM1 is linked to Cirrhosis.