High levels of CXCL10 are present in patients with AT, in particular in the presence of hypothyroidism, and an involvement of T-helper (Th)1 immune response in the induction of AT [97, 115–117], GD, and Graves' ophthalmopathy [97–100, 118] has been demonstrated, suggesting that intrathyroidal lymphocytes and/or thyrocytes may be the source of CXCL10 [119]. This evidence concerns the gene CXCL10 and hypothyroidism.