BRIP1 and neoplasm: As proposed for the tumor suppressor and HR factor BRCA2 as well as the DNA damage sensor poly (ADP-ribose) polymerase 1 (PARP1; Schlacher et al., 2011; Ying et al., 2012), FANCJ may help to prevent uncontrolled MRE11-dependent degradation of stalled replication forks by inhibiting its nuclease activity.