Supporting that multiple pathways contribute to high fidelity repair after UV irradiation, similar to skin tumors from XP patients (Dumaz et al., 1993), MMR-deficient (Borgdorff et al., 2006) and FANCJ-deficient (Guillemette et al., 2014) cells display an elevated frequency of UV-induced C > T point mutations. This evidence concerns the gene BRIP1 and skin neoplasm.