LGALS9 and neoplasm: On the other hand, EVs from tumor cell lines or tumor-bearing patients were found to carry various immunosuppressive molecules that when tested in vitro, induced T cell apoptosis via Fas ligand (FasL) (48, 116–118) and galectin-9 (119, 120), inhibited IL-2-induced T cell proliferation (121), and/or promote differentiation into Tregs (122, 123).