Of interest, IPP was suggested to be increased in stressed cells, such as tumor cells, and its interaction with a specific IPP- (and HMBPP-) binding protein (BTN3A/CD277) leads to Vγ9Vδ2+ T-cell activation (reviewed by the groups of E. Adams, E. Scotet, and T. Hermann in this Research Topic). This evidence concerns the gene IPP and neoplasm.