Indeed in postmortem dorso-lateral prefrontal cortex samples of schizophrenia patients vs. healthy control, increased phosphorylation of NR2B at Y1336 is found (Funk et al., 2012), probably leading to a higher functional activity by reducing endocytosis (Jiang et al., 2011; Li et al., 2011). Here, GRIN2B is linked to schizophrenia.