SNCA and Parkinson disease: In the other report, a group of researchers leaded by Prof Parnetti, assesses the differential role of CSF alpha-synuclein species, tau, and Aβ 42 in PD and conclude that the combination of CSF o/t-α-syn and Aβ 42/tau ratios improve the diagnostic accuracy of PD and that PD patients showing low CSF Aβ 42 levels at baseline are more prone to develop cognitive decline (Parnetti et al., 2014).