Long-term dietary Zn enhancement in transgenic (Tg) mouse models of AD (TgCRND8, Tg2576, and APP/presenilin 1 (PS1) mouse models) has been shown to result in cognitive deficits (Linkous et al., 2009; Railey et al., 2011), as well as an increase in both brain Zn levels and the number and size of Zn-positive plaques in the cortex and hippocampus (Wang et al., 2010). The gene discussed is PSEN1; the disease is Cognitive impairment.