Although a general decline in levels of ZnT3 has been associated with cognitive decline (Bjorklund et al., 2012), it has also been demonstrated that the regions of brain that express ZnT3 may change so that the overall level of expression remains unaltered, but the localization of expression may vary and be centered more around areas of pathology in the Tg CNS (Lee et al., 2012). This evidence concerns the gene SLC30A3 and Mental deterioration.