APOE and Alzheimer disease: In order to examine the effect of excess zinc in the more prevalent form of AD we have developed a late-onset model, examining two types of Tg mice with the (1) humanized ApoE ε4 and mutated hAPP cross (CRND8/E4); or (2) those only with mutated hAPP (CRND8), and investigated the effect of Zn supplementation on spatial memory in these mice.