Subsequently, expression of the glucose transporter GLUT-2 in astrocytes was discovered to be vital for CNS sensing of hypoglycemia when it was shown that overexpression of GLUT-2 in astrocytes was sufficient to restore hypoglycemia-induced peripheral glucagon release in animals with GLUT-2 deficiency (Ripglut1;glut2−/– mice; Marty et al., 2005). This evidence concerns the gene SLC2A2 and Hypoglycemia.