SOD1 and amyotrophic lateral sclerosis: Although previous studies have demonstrated the induction of chromatolysis with fragmentation of the RER in motor neurons of both ALS patients and murine models of ALS (Kusaka et al., 1988; Oyanagi et al., 2008; Sasaki, 2010), we have investigated the cellular basis of RER alterations that leads to translational inhibition in the mutant SOD1 mice.