SOD1 and amyotrophic lateral sclerosis: Since disruption of the protein synthesis machinery (Nissl bodies) with accumulation of misfolded proteins is a manifestation of the ER stress response in the ALS-linked SOD1 mutants (Kikuchi et al., 2006), we analyzed whether this mutation induced the formation of SGs containing stellated translational initiation complexes (Kedersha et al., 2013).