Moreover a number of studies have linked differential miRNAs expression to pathology in AD such as deposition of amyloid plaques and NFTs, as well as more specific pathway interactions and regulatory functions of the amyloid pathway, including regulation of amyloid protein precursor (APP) and beta-site APP cleaving enzyme 1 (β-secretase, BACE1; reviewed in Gustaw-Rothenberg et al., 2010; Geekiyanage et al., 2012). Here, BACE1 is linked to Alzheimer disease.