The stimulation of activated HSCs by TGF-β is believed to be a crucial fibrogenic response in liver fibrosis for the following reasons: higher TGF-β expression in activated HSC; potency of TGF-β to upregulate ECM expression; higher expression of TGF-β receptors in relation to HSCs; and increased expression of TIMP-1/TGF-β liver fibrosis induced [87, 88]. The gene discussed is TIMP1; the disease is Hepatic fibrosis.