Interestingly, in Chagas’ disease, which is caused by Trypanosoma cruzi infection but presents with severe cardiac symptoms (cardiomegaly, ventricular dilatation), the increased oxidative/nitrosative stress associated with this disease was shown to cause nitration of Ig-repeats from the cardiac N2B-titin isoform, and the nitrated peptides were detectable in the plasma from a rat model and from patients (Dihman et al. 2008). The gene discussed is TTN; the disease is Chagas disease.