IMD-0560 potently inhibited TNFα-induced IL-6 production in human fibroblast-like synoviocytes derived from rheumatoid arthritis patients (HFLS-RA) cells and TNFα-induced NF-κB activation in HEK293T cells without causing cell toxicity, although its potency greatly varies depending on the cell type, incubation time and other conditions [22-24]. Here, NFKB1 is linked to rheumatoid arthritis.