Using the SCID-Hu mouse model of prostate cancer bone metastasis, we showed that, in addition to inhibition of tumor growth, maspin expression in transfected prostate cancer DU145 cells induced glandular redifferentiation in vivo with concomitant reduction in bone osteolysis and angiogenesis and increase in fibrosis and collagen remodeling [11]. The gene discussed is SERPINB5; the disease is prostate carcinoma.