Among the bio-molecular factors tested (EGFR gene mutations; EGFR, pAKT, HER-2, ERα, ERβ1, ERβ2, E-CADHERIN, VIMENTIN, pan-hMENA, and hMENA11a protein expression), pan-hMENA and hMENA11a expression, evaluated as continuous variables derived from the product of staining intensity and percentage of positive cells, were the only significant predictors of disease-free survival (DFS) and cancer-specific survival (CSS) (p≤0.08) and DFS and overall survival (OS) (p≤0.07), respectively, at multivariate analysis. The gene discussed is ERBB2; the disease is cancer.