[47], [48] In addition, CSE may be one of the adhesion molecules involved in the adherence between cancer cells and stroma. It was shown that pretreatment of ovarian cancer cells with the chondroitin sulfate cleaving enzyme chondroitinase ABC decreased cell adhesion to the ECM proteins fibronectin, type IV collagen and laminin, and mesothelial cells [49], [50]. The gene discussed is LAMB2; the disease is cancer.