RYR2 and cardiac rhythm disease: Genetic diseases leading to cardiac arrhythmia [catecholaminergic polymorphic ventricular tachycardia (CPVT1) and arrhythmogenic right ventricular dysplasia (ARVD2)] are caused by RyR2 mutations that increase the diastolic calcium leak (Durham et al., 2007 ▶; Yano et al., 2006 ▶).