rs3848719 in the ZNF335 gene is not associated significantly with susceptibility, however the SNP is associated with a decreased APACHEII score when the highest and lowest score quartiles are compared in the total ARDS population (p = 0.032, OR = 0.55, 95%CI 1.27–2.05), and with an increased 60-day mortality in Caucasian and pneumonia groups (p<0.05). Here, ZNF335 is linked to pneumonia.