OPTN and open-angle glaucoma: In human, several loci [5]–[6] and several genes including, contactin 4 (CNTN4) [7], myocilin (MYOC)[8], neurotrohin 4 (NTF4)[9], optineurin (OPTN)[10] and WD repeat domain 36 (WDR36)[11] have been associated with POAG.