Since altered proton gradients established through upregulated NHE activity sensitise tumour cells much more than normal cells to intracellular acid damage when NHEs are inhibited [46], selective inhibition by [Pt(acac)2(DMS)] of the molecular mechanisms leading to NHE1 activation may therefore represent an alternative approach to decrease cancer invasion and motility. The gene discussed is SLC9A1; the disease is neoplasm.