It is worth to mention that KCa3.1 channels contribute to a variety of pathologies such as acute and chronic inflammation [60], [61], vasculo-occlusive disease (neointima formation) [12], atherosclerosis [62], angiogenesis [22], polycystic kidney disease [63], ulcerative colitis [21], [64], tumor growth and metastasis (e.g. glioblastoma [17]), transplant vasculopathy [65], [66], and organ fibrosis [67]. This evidence concerns the gene KCNN4 and polycystic kidney disease.