Cxcr6−/− mice lacking type-I NKT cells were protected against acute- and chronic liver failure in two independent models of liver fibrosis, showed significantly attenuated hepatic inflammation and reduced levels of pro-inflammatory cytokines like tumor necrosis factor (TNF), monocyte chemoattractant protein-1 (MCP-1) and interferon-γ (IFNγ). Here, CCL2 is linked to Hepatic fibrosis.