Previous studies, utilizing the zebrafish model system, have shown that Cxcr2 receptor signaling axis is involved in both long-range systemic neutrophil mobilization from hematopoietic tissue as well as local recruitment to infection or purified Cxcl8 (IL-8, a potent Cxcr2 ligand) [17], [18]. This evidence concerns the gene CXCL8 and infection.