Interestingly, Rnd3 is down-regulated in different cancer cells, such as breast cancer cells [8], hepatocellular carcinoma [10], squamous cell carcinoma [11], mesenchymal tumor cells [12], etc. However, studies of the expression and biological function of Rnd3 in NSCLC are very limited. This evidence concerns the gene RND3 and non-small cell lung carcinoma.