ANG and amyotrophic lateral sclerosis: For example, missense mutations in genes such as SOD1, FUS/TLS, TARDBP, ANG, VAPB, DAO, OPTN, VCP, and a recently identified hexanucleotide-repeat expansion (GGGGCC) in C9ORF72 have been documented to be ALS causative [2]–[5].