We also observed an increase in albuminuria in low-dose STZ eNOS −/− mice as early as at 6 weeks after STZ injections [32]; however, in other STZ studies, the increases in albuminuria were not observed in STZ eNOS −/− mice at 1.5–3 months after diabetes induction [33, 34]. The gene discussed is NOS3; the disease is diabetes mellitus.