NOS3 and liver dysplastic nodule: The authors also demonstrated that TF levels correlate with albuminuria, GBM thickening, and tubulointerstitial fibrosis; TF expression is increased before the development of DN; TF neutralizing antibody prominently decreases renal expression of inflammatory and fibrogenic genes in diabetic mice regardless of eNOS genotype; high-fat diet additively increases renal TF levels and activities [34].