Therefore, it is still unclear whether “eNOS deficiency accelerates DN” or “diabetes accelerates the renal injury in eNOS −/− mice.” Also, eNOS is expressed in various cell types including cardiomyocytes, hematopoietic cells such as erythrocytes and platelets, adipocytes, and renal tubular epithelial cells [103, 104]. The gene discussed is NOS3; the disease is diabetes mellitus.