Notably, among the three signatures TMtb-iNet showed the highest positive correlation with both CD4+ and CD8+ T cells from acute and chronic forms of HIV infection (e.g., in CD4_chronic HIV, NES = 3.35 for TMtb-iNet versus NES = 3.06 for THP1r2Mtb-induced signature or NES = 1.59 for TMtb-iEx) (Table 6 and Figure 8). The gene discussed is CD4; the disease is HIV infectious disease.