Moreover, PKCβ can be activated by hyperglycemia and oxidative stimulus in renal tubular cells and it is accompanied with phosphorylation of p66Shc [8, 14, 28], and inhibition of PKCβ could partially prevent p66Shc phosphorylation and its mitochondrial translocation in HK-2 cells treated with HG [12]. The gene discussed is PRKCB; the disease is Hyperglycemia.