In mice, CHD1L activates the expression of Sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1 (SPOCK1), which activates Akt signaling to block apoptosis and invasion by HCC cells, and levels of SPOCK1 increase with the progression of human HCC (14). This evidence concerns the gene SPOCK1 and hepatocellular carcinoma.