VWF and endothelial dysfunction: In keeping with this hypothesis, we demonstrated that patients who received rosiglitazone were more likely to show a decrease in cfDNA levels after 8 weeks than those who received placebo (although absolute differences in cfDNA levels were not statistically significant) and that cfDNA levels correlated to levels of vWF and cfDNA, established markers of endothelial dysfunction [40, 41].